Ap1g1 | adaptor protein complex AP-1, gamma 1 subunit
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging
11 No significant impact
6 Not tested
Data collections
Gene metrics:10Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| hyperactivity | 5 supporting datasets | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.65x10-7 | ||
| decreased lean body mass | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.16x10-9 | ||
| increased total body fat amount | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.68x10-7 | ||
| abnormal optic disk morphology | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.84x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.6x10-12 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| increased vertical activity | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.3x10-6 | ||
| abnormal retina morphology | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.19x10-7 | ||
| cataract | 1 supporting dataset | Ap1g1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.49x10-7 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 50% (1/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 50% (1/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 50% (1/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ap1g1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ap1g1.
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| Ap1g1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ap1g1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ap1g1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |