Ap1g1 | adaptor protein complex AP-1, gamma 1 subunit

GeneMGI:101919Synonyms: gamma-adaptin, D8Ertd374e, +1 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

3Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hyperactivity	5 supporting datasets	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.65x10^-7
decreased lean body mass	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.16x10^-9
increased total body fat amount	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.68x10^-7
abnormal optic disk morphology	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.84x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.6x10^-12
embryonic lethality prior to organogenesis	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
increased vertical activity	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.3x10^-6
abnormal retina morphology	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.19x10^-7
cataract	1 supporting dataset	Ap1g1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.49x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ap1g1.

Associated images

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Histopathology

There is no histopathology data found for Ap1g1.

IMPC related publications

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External links

No external links available for Ap1g1.

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*Ap1g1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ap1g1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ap1g1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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