Tead1 | TEA domain family member 1

GeneMGI:101876Synonyms: TEF-1, TEAD-1, +5 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Embryo Growth/size/body region Nervous system Vision/eye Skeleton Mortality/aging Craniofacial

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Tead1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal tooth morphology	1 supporting dataset	Tead1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.86x10^-5
abnormal embryo turning	1 supporting dataset	Tead1^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal retina morphology	1 supporting dataset	Tead1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.03x10^-7
decreased prepulse inhibition	1 supporting dataset	Tead1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.12x10^-7
decreased cornea thickness	2 supporting datasets	Tead1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.93x10^-8
abnormal embryo size	1 supporting dataset	Tead1^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Tead1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal eye anterior chamber depth	1 supporting dataset	Tead1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.03x10^-5
increased total body fat amount	2 supporting datasets	Tead1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.87x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tead1.

Associated images

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Histopathology

There is no histopathology data found for Tead1.

IMPC related publications

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External links

No external links available for Tead1.

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*Tead1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tead1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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