Traf2 | TNF receptor-associated factor 2

GeneMGI:101835

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Traf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased alpha-beta T cell number	1 supporting dataset	Traf2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Traf2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
increased circulating chloride level	1 supporting dataset	Traf2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.58x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Traf2.

Associated images

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Histopathology

There is no histopathology data found for Traf2.

IMPC related publications

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External links

No external links available for Traf2.

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*Traf2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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