Gja8 | gap junction protein, alpha 8

GeneMGI:99953Synonyms: alpha 8 connexin, dcm, +5 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Renal/urinary system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

7Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased circulating amylase level	1 supporting dataset	Gja8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.07x10^-11
abnormal retina morphology	1 supporting dataset	Gja8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.79x10^-14
increased kidney weight	1 supporting dataset	Gja8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.05x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gja8.

Associated images

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Histopathology

There is no histopathology data found for Gja8.

IMPC related publications

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External links

No external links available for Gja8.

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*Gja8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Gja8^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gja8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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