Kcnma1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1

GeneMGI:99923Synonyms: mSlo1, 5730414M22Rik, +5 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Behavior/neurological

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal gait	1 supporting dataset	Kcnma1^em1(IMPC)H	homozygote	Early adult	4.05x10^-26
tremors	1 supporting dataset	Kcnma1^em1(IMPC)H	homozygote	Early adult	1.37x10^-6
abnormal locomotor behavior	1 supporting dataset	Kcnma1^em1(IMPC)H	homozygote	Early adult	1.68x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Kcnma1^em1(IMPC)H	homozygote	Early adult	3.23x10^-8
abnormal ear morphology	1 supporting dataset	Kcnma1^em1(IMPC)H	homozygote	Early adult	1.51x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kcnma1.

Associated images

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Histopathology

There is no histopathology data found for Kcnma1.

IMPC related publications

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External links

No external links available for Kcnma1.

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*Kcnma1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Kcnma1^em2(IMPC)H*	Exon Deletion	‌	mouse
*Kcnma1^em3H*	Point Mutation	‌	mouse
*Kcnma1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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