Ppm1a | protein phosphatase 1A, magnesium dependent, alpha isoform

GeneMGI:99878Synonyms: MPPa-1, 2310003C21Rik, +3 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Skeleton

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral content	1 supporting dataset	Ppm1a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.64x10^-5
limb grasping	1 supporting dataset	Ppm1a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.28x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Ppm1a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.55x10^-6
abnormal bone structure	1 supporting dataset	Ppm1a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.77x10^-6
increased grip strength	1 supporting dataset	Ppm1a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.58x10^-5
short tibia	1 supporting dataset	Ppm1a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.75x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppm1a.

Associated images

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Histopathology

There is no histopathology data found for Ppm1a.

IMPC related publications

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External links

No external links available for Ppm1a.

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*Ppm1a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ppm1a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ppm1a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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