Rasgrf1 | RAS protein-specific guanine nucleotide-releasing factor 1
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Growth/size/body region Behavior/neurological
17 No significant impact
5 Not tested
Data collections
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased lean body mass | 1 supporting dataset | Rasgrf1tm1bNarl | homozygote | Early adult | 4.63x10-5 | ||
| hyperactivity | 2 supporting datasets | Rasgrf1tm1bNarl | homozygote | Early adult | 2.94x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Rasgrf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rasgrf1.
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