Cntfr | ciliary neurotrophic factor receptor

GeneMGI:99605Synonyms: Cntfralpha

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal behavior	2 supporting datasets	Cntfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.59x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Cntfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.52x10^-5
preweaning lethality, complete penetrance	2 supporting datasets	Cntfr^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased leukocyte cell number	1 supporting dataset	Cntfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.66x10^-5
increased circulating cholesterol level	1 supporting dataset	Cntfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.61x10^-6
increased circulating serum albumin level	1 supporting dataset	Cntfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.87x10^-7
increased lactate dehydrogenase level	1 supporting dataset	Cntfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.53x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cntfr.

Associated images

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Histopathology

There is no histopathology data found for Cntfr.

IMPC related publications

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External links

No external links available for Cntfr.

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*Cntfr^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cntfr^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cntfr^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Cntfr^{tm376(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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