Adora2a | adenosine A2a receptor
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological
11 No significant impact
7 Not tested
Data collections
Gene metrics:10Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating alanine transaminase level | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Late adult | 3.26x10-27 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Late adult | 5.89x10-13 | ||
| increased freezing behavior | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Late adult | 1.8x10-6 | ||
| decreased lean body mass | 2 supporting datasets | Adora2aem1(IMPC)H | homozygote | Late adult | 3.98x10-8 | ||
| increased total body fat amount | 2 supporting datasets | Adora2aem1(IMPC)H | homozygote | Late adult | 2.62x10-8 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Late adult | 1.21x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Early adult | 5.39x10-5 | ||
| increased circulating glucose level | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Early adult | 5.26x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Early adult | 5.56x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Adora2aem1(IMPC)H | homozygote | Late adult | 8.99x10-5 |
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Human diseases caused by Adora2a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Adora2a.
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| Adora2aem1(IMPC)H | Exon Deletion | | mouse |
| Adora2aem2(IMPC)H | Exon Deletion | | mouse |
| Adora2atm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Adora2atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Adora2atm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Adora2atm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |