Zscan21 | zinc finger and SCAN domain containing 21
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Integument Vision/eye Mortality/aging
14 No significant impact
5 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| abnormal skin coloration | 1 supporting dataset | Zscan21tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 5.72x10-6 | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Zscan21tm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased total retina thickness | 2 supporting datasets | Zscan21tm2b(EUCOMM)Wtsi | homozygote | Early adult | 6.47x10-8 | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Zscan21tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.59x10-5 | ||
| male infertility | 1 supporting dataset | Zscan21tm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased total retina thickness | 2 supporting datasets | Zscan21tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 7.71x10-6 | ||
| decreased respiratory quotient | 1 supporting dataset | Zscan21tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 4.84x10-6 | ||
| female infertility | 1 supporting dataset | Zscan21tm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Zscan21 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zscan21.
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| Zscan21tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zscan21tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Zscan21tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Zscan21tm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Zscan21tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |