Pgc | progastricsin (pepsinogen C)
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Hematopoietic system Cardiovascular system
13 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged heart | 1 supporting dataset | Pgcem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal testis morphology | 1 supporting dataset | Pgcem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Pgcem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Pgcem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Pgcem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| small testis | 1 supporting dataset | Pgcem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased prepulse inhibition | 1 supporting dataset | Pgcem1(IMPC)Ccpcz | homozygote | Early adult | 2.43x10-5 |
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Human diseases caused by Pgc mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pgc.
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| Pgcem1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Pgctm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Pgctm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pgctm402444(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |