U2af2 | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
GeneMGI:98886
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system Skeleton Mortality/aging
12 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | U2af2em1(IMPC)J | homozygote | E9.5 | N/A * | ||
| increased leukocyte cell number | 1 supporting dataset | U2af2em1(IMPC)J | heterozygote | Early adult | 5.44x10-5 | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | U2af2em1(IMPC)J | heterozygote | Early adult | 1.52x10-7 | ||
| decreased circulating calcium level | 1 supporting dataset | U2af2em1(IMPC)J | heterozygote | Early adult | 4.71x10-6 | ||
| abnormal auditory brainstem response | 1 supporting dataset | U2af2em1(IMPC)J | heterozygote | Early adult | 4.23x10-5 | ||
| increased bone mineral density | 1 supporting dataset | U2af2em1(IMPC)J | heterozygote | Early adult | 7.11x10-9 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | U2af2em1(IMPC)J | homozygote | Early adult | N/A * |
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External links
No external links available for U2af2.
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| U2af2em1(IMPC)J | Exon Deletion | | mouse |
| U2af2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| U2af2tm404224(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |