Twist1 | twist basic helix-loop-helix transcription factor 1

GeneMGI:98872Synonyms: pdt, charlie chaplin, +5 more

Physiological systems

15 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Integument Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Skeleton Craniofacial

8 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal nail morphology	1 supporting dataset	Twist1^{em1(IMPC)Rbrc}	heterozygote	Late adult	7.39x10^-14
abnormal pelvic girdle bone morphology	1 supporting dataset	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.67x10^-6
abnormal brain morphology	2 supporting datasets	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	N/A ^*
abnormal nail morphology	2 supporting datasets	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.74x10^-15
abnormal autopod morphology	2 supporting datasets	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.74x10^-15
abnormal digit morphology	3 supporting datasets	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.23x10^-21
abnormal vertebral arch morphology	2 supporting datasets	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	2.39x10^-6
abnormal cranium morphology	1 supporting dataset	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.18x10^-10
decreased total body fat amount	1 supporting dataset	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	1.39x10^-5
abnormal zygomatic bone morphology	1 supporting dataset	Twist1^{em1(IMPC)Rbrc}	heterozygote	Early adult	6.97x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Twist1.

Associated images

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Histopathology

There is no histopathology data found for Twist1.

IMPC related publications

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External links

No external links available for Twist1.

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*Twist1^{em1(IMPC)Rbrc}*	Whole-gene deletion	‌	mouse
*Twist1^{tm413867(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes