Top2b | topoisomerase (DNA) II beta

GeneMGI:98791Synonyms: Top-2, D230016L12Rik

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Embryo Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Mortality/aging Craniofacial

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



small spleen	2 supporting datasets	Top2b^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
edema	1 supporting dataset	Top2b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal spleen morphology	2 supporting datasets	Top2b^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Top2b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Top2b^em1(IMPC)Mbp	heterozygote	Early adult	9.02x10^-8
preweaning lethality, complete penetrance	3 supporting datasets	Top2b^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Top2b^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
cleft palate	1 supporting dataset	Top2b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal head shape	1 supporting dataset	Top2b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Top2b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Top2b.

Associated images

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Histopathology

There is no histopathology data found for Top2b.

IMPC related publications

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External links

No external links available for Top2b.

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*Top2b^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Top2b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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