Thra | thyroid hormone receptor alpha

GeneMGI:98742Synonyms: T3R[a], c-erbAalpha, +9 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hyperactivity	16 supporting datasets	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.16x10^-59
increased bone mineral density	1 supporting dataset	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.23x10^-6
increased bone mineral content	2 supporting datasets	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.64x10^-6
hyperactivity	7 supporting datasets	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Late adult	9.55x10^-12
increased hematocrit	1 supporting dataset	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Late adult	5.39x10^-5
limb grasping	1 supporting dataset	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.3x10^-6
preweaning lethality, incomplete penetrance	2 supporting datasets	Thra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal contextual conditioning behavior	4 supporting datasets	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.01x10^-5
increased startle reflex	1 supporting dataset	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.13x10^-9
increased circulating alkaline phosphatase level	1 supporting dataset	Thra^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.2x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Thra.

Associated images

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Histopathology

There is no histopathology data found for Thra.

IMPC related publications

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External links

No external links available for Thra.

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*Thra^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Thra^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Thra^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Thra^{tm357(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Thra^{tm43807(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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