Thra | thyroid hormone receptor alpha
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging
12 No significant impact
2 Not tested
Gene metrics:23Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues
| hyperactivity | 16 supporting datasets | Thratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.16x10-59 | ||
| increased bone mineral density | 1 supporting dataset | Thratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.23x10-6 | ||
| increased bone mineral content | 2 supporting datasets | Thratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.64x10-6 | ||
| hyperactivity | 7 supporting datasets | Thratm1b(EUCOMM)Wtsi | heterozygote | Late adult | 9.55x10-12 | ||
| increased hematocrit | 1 supporting dataset | Thratm1b(EUCOMM)Wtsi | heterozygote | Late adult | 5.39x10-5 | ||
| limb grasping | 1 supporting dataset | Thratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.3x10-6 | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Thratm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal contextual conditioning behavior | 4 supporting datasets | Thratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.01x10-5 | ||
| increased startle reflex | 1 supporting dataset | Thratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.13x10-9 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Thratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.2x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Thra mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Thra.
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| Thratm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Thratm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Thratm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Thratm357(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Thratm43807(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |