Tgfbr2 | transforming growth factor, beta receptor II
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Growth/size/body region Liver/biliary system Cardiovascular system Mortality/aging Renal/urinary system
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal heart morphology | 1 supporting dataset | Tgfbr2em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| small liver | 1 supporting dataset | Tgfbr2em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Tgfbr2em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Tgfbr2em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Tgfbr2em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Tgfbr2em1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Tgfbr2em1(IMPC)Rbrc | homozygote | Early adult | N/A * |
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Human diseases caused by Tgfbr2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tgfbr2.
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| Tgfbr2em1(IMPC)Rbrc | Exon Deletion | | mouse |
| Tgfbr2tm189785(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |