Tbx3 | T-box 3
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Behavior/neurological Cardiovascular system Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Tbx3em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| eye hemorrhage | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | 5.84x10-6 | ||
| decreased locomotor activity | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | 1.49x10-5 | ||
| abnormal lymph node morphology | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | 1.82x10-5 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | 6.32x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| microphthalmia | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Tbx3em1(IMPC)Mbp | heterozygote | Early adult | 3.73x10-6 |
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Human diseases caused by Tbx3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tbx3.
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| Tbx3em1(IMPC)Mbp | Exon Deletion | | mouse |
| Tbx3tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |