Slc6a6 | solute carrier family 6 (neurotransmitter transporter, taurine), member 6

GeneMGI:98488Synonyms: Taut

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

14 No significant impact

4 Not tested

Gene metrics:12Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

impaired pupillary reflex1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult2.91x10-11 
decreased fasting circulating glucose level1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult4.47x10-6 
decreased thigmotaxis2 supporting datasetsSlc6a6em1(IMPC)MbphomozygoteEarly adult3.82x10-8 
decreased erythrocyte cell number1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult6.19x10-6 
increased circulating phosphate level1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult6.03x10-14 
abnormal retina morphology1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult4.35x10-5 
prolonged RR interval1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult8.51x10-10 
increased blood urea nitrogen level1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult5.58x10-6 
increased monocyte cell number1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adult6.73x10-5 
enlarged lymph nodes1 supporting datasetSlc6a6em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Slc6a6em1(IMPC)MbpExon Deletionmouse

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