Sparc | secreted acidic cysteine rich glycoprotein
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Growth/size/body region Limbs/digits/tail Vision/eye Skeleton Craniofacial
13 No significant impact
3 Not tested
Data collections
Gene metrics:16Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
decreased bone mineral density | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.32x10-6 | ||
decreased body weight | 3 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.03x10-5 | ||
cataract | 2 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.29x10-12 | ||
increased circulating calcium level | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.54x10-5 | ||
increased circulating alanine transaminase level | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.32x10-6 | ||
abnormal incisor color | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.12x10-9 | ||
abnormal coat/hair pigmentation | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.66x10-7 | ||
increased circulating creatine kinase level | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.99x10-6 | ||
abnormal lens morphology | 2 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.85x10-12 | ||
abnormal eye morphology | 2 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.15x10-7 |
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External links
No external links available for Sparc.
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Sparctm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | es cell |
Sparctm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
Sparctm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell |