Sparc | secreted acidic cysteine rich glycoprotein
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Growth/size/body region Limbs/digits/tail Vision/eye Skeleton Craniofacial
13 No significant impact
3 Not tested
Data collections
Gene metrics:16Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased bone mineral density | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.32x10-6 | ||
| decreased body weight | 3 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.03x10-5 | ||
| cataract | 2 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.29x10-12 | ||
| increased circulating calcium level | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.54x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.32x10-6 | ||
| abnormal incisor color | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.12x10-9 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.66x10-7 | ||
| increased circulating creatine kinase level | 1 supporting dataset | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.99x10-6 | ||
| abnormal lens morphology | 2 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.85x10-12 | ||
| abnormal eye morphology | 2 supporting datasets | Sparctm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.15x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Sparc mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sparc.
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| Sparctm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Sparctm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sparctm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |