Sparc | secreted acidic cysteine rich glycoprotein

GeneMGI:98373Synonyms: BM-40, osteonectin

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Growth/size/body region Limbs/digits/tail Vision/eye Skeleton Craniofacial

13 No significant impact

3 Not tested

Gene metrics:16Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

decreased bone mineral density1 supporting datasetSparctm1a(EUCOMM)WtsihomozygoteEarly adult9.32x10-6 
decreased body weight3 supporting datasetsSparctm1a(EUCOMM)WtsihomozygoteEarly adult1.03x10-5 
cataract2 supporting datasetsSparctm1a(EUCOMM)WtsihomozygoteEarly adult1.29x10-12 
increased circulating calcium level1 supporting datasetSparctm1a(EUCOMM)WtsihomozygoteEarly adult3.54x10-5 
increased circulating alanine transaminase level1 supporting datasetSparctm1a(EUCOMM)WtsihomozygoteEarly adult6.32x10-6 
abnormal incisor color1 supporting datasetSparctm1a(EUCOMM)WtsihomozygoteEarly adult5.12x10-9 
abnormal coat/hair pigmentation1 supporting datasetSparctm1a(EUCOMM)WtsihomozygoteEarly adult1.66x10-7 
increased circulating creatine kinase level1 supporting datasetSparctm1a(EUCOMM)WtsihomozygoteEarly adult5.99x10-6 
abnormal lens morphology2 supporting datasetsSparctm1a(EUCOMM)WtsihomozygoteEarly adult2.85x10-12 
abnormal eye morphology2 supporting datasetsSparctm1a(EUCOMM)WtsihomozygoteEarly adult1.15x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sparctm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Sparctm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
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Sparctm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
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