Spi1 | Spi-1 proto-oncogene
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Hematopoietic system Mortality/aging Cardiovascular system
18 No significant impact
3 Not tested
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
25Embryo tissues
| hemorrhage | 1 supporting dataset | Spi1tm2b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| decreased erythrocyte cell number | 1 supporting dataset | Spi1tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 4.91x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Spi1tm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular volume | 1 supporting dataset | Spi1tm2b(EUCOMM)Wtsi | heterozygote | Early adult | 1.83x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Spi1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Spi1.
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| Spi1em1(IMPC)Wtsi | Point Mutation | | mouse |
| Spi1tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Spi1tm199198(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Spi1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Spi1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Spi1tm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Spi1tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Spi1tm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |