Rmrp | RNA component of mitochondrial RNAase P
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
13 No significant impact
3 Not tested
Data collections
Gene metrics:9Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal skin morphology | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased circulating cholesterol level | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | 9.8x10-10 | ||
| increased lymphocyte cell number | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | 4.54x10-5 | ||
| abnormal spleen morphology | 2 supporting datasets | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | 5.63x10-11 | ||
| small heart | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased kidney weight | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | 9.05x10-5 | ||
| enhanced cued conditioning behavior | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | 8.85x10-6 | ||
| abnormal heart morphology | 1 supporting dataset | Rmrpem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * |
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Human diseases caused by Rmrp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rmrp.
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| Rmrpem1(IMPC)Ccpcz | Whole-gene deletion | | mouse |