Pygm | muscle glycogen phosphorylase
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging
11 No significant impact
7 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating calcium level | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | 4.91x10-13 | ||
| decreased grip strength | 2 supporting datasets | Pygmem1(IMPC)J | homozygote | Early adult | 8.99x10-11 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | 8.91x10-90 | ||
| prolonged RR interval | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | 1.12x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | 4.89x10-7 | ||
| decreased bone mineral content | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | 9.66x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | 1.24x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | 7.51x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Pygmem1(IMPC)J | homozygote | Early adult | N/A * |
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Human diseases caused by Pygm mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pygm.
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| Pygmem1(IMPC)J | Exon Deletion | | mouse |
| Pygmtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pygmtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pygmtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pygmtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Pygmtm45980(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |