Plcb1 | phospholipase C, beta 1

GeneMGI:97613Synonyms: 3110043I21Rik

Physiological systems

19 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Renal/urinary system

9 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged spleen	1 supporting dataset	Plcb1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Plcb1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Plcb1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
hyperactivity	4 supporting datasets	Plcb1^em1(IMPC)Mbp	heterozygote	Early adult	1.06x10^-13
cataract	1 supporting dataset	Plcb1^em1(IMPC)Mbp	heterozygote	Late adult	3.08x10^-6
enlarged spleen	2 supporting datasets	Plcb1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal lymph node morphology	2 supporting datasets	Plcb1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
enlarged kidney	1 supporting dataset	Plcb1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Plcb1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Plcb1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plcb1.

Associated images

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Histopathology

There is no histopathology data found for Plcb1.

IMPC related publications

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External links

No external links available for Plcb1.

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*Plcb1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Plcb1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Plcb1^{tm42685(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes