Prkcz | protein kinase C, zeta
Physiological systems
21 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
20 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased circulating alkaline phosphatase level | 1 supporting dataset | Prkcztm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.27x10-10 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Prkcztm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.45x10-12 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Prkcztm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.12x10-10 | ||
| increased circulating LDL cholesterol level | 1 supporting dataset | Prkcztm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.07x10-6 | ||
| increased lactate dehydrogenase level | 1 supporting dataset | Prkcztm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.75x10-15 | ||
| decreased circulating creatinine level | 1 supporting dataset | Prkcztm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.1x10-5 | ||
| increased circulating iron level | 1 supporting dataset | Prkcztm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.54x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Prkcz mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Prkcz.
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| Prkcztm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Prkcztm1.1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | ES Cell |
| Prkcztm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Prkcztm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |