Prkch | protein kinase C, eta
Physiological systems
17 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Growth/size/body region Behavior/neurological
15 No significant impact
7 Not tested
Data collections
Gene metrics:2Significant phenotypes
1Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| decreased grip strength | 1 supporting dataset | Prkchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.88x10-5 | ||
| increased lean body mass | 1 supporting dataset | Prkchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.74x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Prkch mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prkch.
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| Prkchtm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Prkchtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Prkchtm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Prkchtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |