Pcsk1 | proprotein convertase subtilisin/kexin type 1

GeneMGI:97511Synonyms: SPC3, prohormone convertase 1/3, +5 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



persistence of hyaloid vascular system	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.72x10^-8
abnormal retina blood vessel morphology	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.62x10^-5
decreased locomotor activity	4 supporting datasets	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.85x10^-18
abnormal retina vasculature morphology	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.86x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal freezing behavior	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.39x10^-5
abnormal vitreous body morphology	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.85x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pcsk1.

Associated images

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Histopathology

There is no histopathology data found for Pcsk1.

IMPC related publications

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External links

No external links available for Pcsk1.

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*Pcsk1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pcsk1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pcsk1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Pcsk1^{tm44480(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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