Pah | phenylalanine hydroxylase

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Pigmentation Endocrine/exocrine gland Integument Vision/eye Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



small adrenal glands	1 supporting dataset	Pah^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal sternum morphology	1 supporting dataset	Pah^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Pah^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Pah^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
abnormal cornea morphology	1 supporting dataset	Pah^em1(IMPC)Tcp	homozygote	Early adult	2.38x10^-5
abnormal coat/hair pigmentation	3 supporting datasets	Pah^em1(IMPC)Tcp	homozygote	Early adult	3.33x10^-6
abnormal sternum morphology	1 supporting dataset	Pah^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
female infertility	1 supporting dataset	Pah^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Pah^em1(IMPC)Tcp	heterozygote	Early adult	6.07x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pah.

Associated images

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Histopathology

There is no histopathology data found for Pah.

IMPC related publications

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External links

No external links available for Pah.

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*Pah^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Pah^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Pah^{tm115813(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Pah^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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