Ntf5 | neurotrophin 5
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:10Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal locomotor behavior | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.72x10-7 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.94x10-5 | ||
| prolonged QT interval | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.13x10-5 | ||
| tremors | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.4x10-7 | ||
| increased circulating cholesterol level | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.11x10-6 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.27x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.15x10-6 | ||
| prolonged QRS complex duration | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.34x10-8 | ||
| female infertility | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating total protein level | 1 supporting dataset | Ntf5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.98x10-5 |
| | | | | | | | | | |
Human diseases caused by Ntf5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ntf5.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ntf5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ntf5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ntf5tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ntf5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |