Nkx2-6 | NK2 homeobox 6
Physiological systems
16 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
15 No significant impact
8 Not tested
Data collections
Gene metrics:2Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating potassium level | 1 supporting dataset | Nkx2-6em1(IMPC)H | homozygote | Early adult | 3.71x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Nkx2-6em1(IMPC)H | homozygote | Early adult | 2.8x10-6 |
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Human diseases caused by Nkx2-6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nkx2-6.
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| Nkx2-6em1(IMPC)H | Intra-exon deletion | | mouse |
| Nkx2-6em2(IMPC)H | Intra-exon deletion | | mouse |
| Nkx2-6tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Nkx2-6tm1.1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | ES Cell |
| Nkx2-6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Nkx2-6tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Nkx2-6tm2(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |