Ngfr | nerve growth factor receptor (TNFR superfamily, member 16)

GeneMGI:97323Synonyms: p75, Tnfrsf16, +4 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Vision/eye Behavior/neurological Mortality/aging

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased locomotor activity	1 supporting dataset	Ngfr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.22x10^-10
abnormal digit morphology	3 supporting datasets	Ngfr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.96x10^-8
increased startle reflex	2 supporting datasets	Ngfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.1x10^-6
tremors	1 supporting dataset	Ngfr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.37x10^-6
decreased thigmotaxis	2 supporting datasets	Ngfr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.17x10^-7
increased circulating phosphate level	1 supporting dataset	Ngfr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.1x10^-5
abnormal gait	1 supporting dataset	Ngfr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.47x10^-15
decreased circulating triglyceride level	1 supporting dataset	Ngfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.91x10^-5
abnormal eye morphology	1 supporting dataset	Ngfr^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.26x10^-5
limb grasping	1 supporting dataset	Ngfr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.45x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ngfr.

Associated images

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Histopathology

There is no histopathology data found for Ngfr.

IMPC related publications

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External links

No external links available for Ngfr.

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*Ngfr^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ngfr^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ngfr^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ngfr^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Ngfr^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Ngfr^{tm73(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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