Ngfr | nerve growth factor receptor (TNFR superfamily, member 16)
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Vision/eye Behavior/neurological Mortality/aging
17 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased locomotor activity | 1 supporting dataset | Ngfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.22x10-10 | ||
| abnormal digit morphology | 3 supporting datasets | Ngfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.96x10-8 | ||
| increased startle reflex | 2 supporting datasets | Ngfrtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.1x10-6 | ||
| tremors | 1 supporting dataset | Ngfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.37x10-6 | ||
| decreased thigmotaxis | 2 supporting datasets | Ngfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.17x10-7 | ||
| increased circulating phosphate level | 1 supporting dataset | Ngfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.1x10-5 | ||
| abnormal gait | 1 supporting dataset | Ngfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.47x10-15 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Ngfrtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 5.91x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Ngfrtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.26x10-5 | ||
| limb grasping | 1 supporting dataset | Ngfrtm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.45x10-14 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Ngfr mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ngfr.
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| Ngfrtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ngfrtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ngfrtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ngfrtm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Ngfrtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Ngfrtm73(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |