Ncf1 | neutrophil cytosolic factor 1

GeneMGI:97283Synonyms: NADPH oxidase subunit (47kDa), p47<phox>, +3 more

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Vision/eye Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



small kidney	1 supporting dataset	Ncf1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal lung morphology	1 supporting dataset	Ncf1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal lymph node morphology	2 supporting datasets	Ncf1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Ncf1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Ncf1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged lymph nodes	2 supporting datasets	Ncf1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Ncf1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Ncf1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased thigmotaxis	2 supporting datasets	Ncf1^em1(IMPC)Mbp	homozygote	Early adult	4.36x10^-7
abnormal kidney morphology	1 supporting dataset	Ncf1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ncf1.

Associated images

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Histopathology

There is no histopathology data found for Ncf1.

IMPC related publications

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External links

No external links available for Ncf1.

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*Ncf1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ncf1^{tm40457(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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