Mag | myelin-associated glycoprotein
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Hearing/vestibular/ear Nervous system Hematopoietic system Behavior/neurological
13 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| abnormal auditory brainstem response | 4 supporting datasets | Magtm1.1(KOMP)Vlcg | homozygote | Early adult | 6.67x10-7 | ||
| decreased coping response | 1 supporting dataset | Magtm1.1(KOMP)Vlcg | homozygote | Early adult | 2x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Magtm1.1(KOMP)Vlcg | homozygote | Early adult | 6.77x10-5 | ||
| abnormal sleep behavior | 1 supporting dataset | Magtm1.1(KOMP)Vlcg | homozygote | Early adult | 3.94x10-6 | ||
| convulsive seizures | 1 supporting dataset | Magtm1.1(KOMP)Vlcg | homozygote | Early adult | 3.75x10-15 | ||
| decreased leukocyte cell number | 1 supporting dataset | Magtm1.1(KOMP)Vlcg | homozygote | Early adult | 7.62x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Mag mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mag.
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| Magtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Magtm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Magtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |