Krt8 | keratin 8
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Nervous system Hematopoietic system Behavior/neurological Mortality/aging
13 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Krt8tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Krt8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.64x10-5 | ||
| improved glucose tolerance | 2 supporting datasets | Krt8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.37x10-5 | ||
| increased neutrophil cell number | 1 supporting dataset | Krt8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.38x10-5 | ||
| increased prepulse inhibition | 1 supporting dataset | Krt8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.71x10-5 |
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Human diseases caused by Krt8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Krt8.
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| Krt8tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Krt8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Krt8tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Krt8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Krt8tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Krt8tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |