Kcne1 | potassium voltage-gated channel, Isk-related subfamily, member 1

GeneMGI:96673Synonyms: nmf190, MinK, +1 more

Physiological systems

16 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

7 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:29Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



hyperactivity	9 supporting datasets	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.03x10^-83
tremors	1 supporting dataset	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.55x10^-6
decreased thigmotaxis	2 supporting datasets	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.24x10^-14
decreased bone mineral content	2 supporting datasets	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.21x10^-12
decreased total body fat amount	1 supporting dataset	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.23x10^-9
abnormal behavior	2 supporting datasets	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.24x10^-21
decreased vertical activity	1 supporting dataset	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.77x10^-9
abnormal startle reflex	1 supporting dataset	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.24x10^-21
increased lean body mass	2 supporting datasets	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.11x10^-5
abnormal auditory brainstem response	5 supporting datasets	Kcne1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.05x10^-21

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kcne1.

Associated images

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Histopathology

There is no histopathology data found for Kcne1.

IMPC related publications

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External links

No external links available for Kcne1.

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*Kcne1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Kcne1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Kcne1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Kcne1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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