Kcnb1 | potassium voltage gated channel, Shab-related subfamily, member 1
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Growth/size/body region Hematopoietic system Behavior/neurological
16 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| hyperactivity | 7 supporting datasets | Kcnb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.29x10-54 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Kcnb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.3x10-5 | ||
| increased exploration in new environment | 1 supporting dataset | Kcnb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.32x10-8 | ||
| increased lean body mass | 1 supporting dataset | Kcnb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.57x10-5 | ||
| abnormal locomotor behavior | 1 supporting dataset | Kcnb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.46x10-6 | ||
| abnormal gait | 1 supporting dataset | Kcnb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.26x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Kcnb1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.97x10-7 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/1) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Kcnb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kcnb1.
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| Kcnb1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Kcnb1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Kcnb1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |