Il2ra | interleukin 2 receptor, alpha chain
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Digestive/alimentary Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
12 No significant impact
4 Not tested
Data collections
Gene metrics:35Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating HDL cholesterol level | 1 supporting dataset | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.27x10-8 | ||
| abnormal duodenum morphology | 1 supporting dataset | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased neutrophil cell number | 2 supporting datasets | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.71x10-6 | ||
| decreased locomotor activity | 6 supporting datasets | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.38x10-9 | ||
| enlarged lymph nodes | 2 supporting datasets | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased circulating calcium level | 1 supporting dataset | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.24x10-5 | ||
| increased circulating phosphate level | 1 supporting dataset | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.16x10-5 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.14x10-8 | ||
| abnormal spleen morphology | 2 supporting datasets | Il2ratm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Il2ra mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Il2ra.
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| Il2ratm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Il2ratm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Il2ratm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Il2ratm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |