Il2ra | interleukin 2 receptor, alpha chain

GeneMGI:96549Synonyms: Il2r, Ly-43, +2 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Digestive/alimentary Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:35Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating HDL cholesterol level	1 supporting dataset	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.27x10^-8
abnormal duodenum morphology	1 supporting dataset	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased neutrophil cell number	2 supporting datasets	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
increased circulating aspartate transaminase level	1 supporting dataset	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.71x10^-6
decreased locomotor activity	6 supporting datasets	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.38x10^-9
enlarged lymph nodes	2 supporting datasets	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating calcium level	1 supporting dataset	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.24x10^-5
increased circulating phosphate level	1 supporting dataset	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.16x10^-5
abnormal vertebrae morphology	1 supporting dataset	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.14x10^-8
abnormal spleen morphology	2 supporting datasets	Il2ra^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Il2ra.

Associated images

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Histopathology

There is no histopathology data found for Il2ra.

IMPC related publications

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External links

No external links available for Il2ra.

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*Il2ra^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Il2ra^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Il2ra^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Il2ra^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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