Hsf1 | heat shock factor 1
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Behavior/neurological Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
46Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Hsf1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.79x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Hsf1tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * | ||
| abnormal sleep behavior | 1 supporting dataset | Hsf1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.89x10-5 | ||
| decreased circulating glucose level | 1 supporting dataset | Hsf1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.42x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Hsf1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Hsf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Hsf1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Hsf1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Hsf1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Hsf1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Hsf1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |