Gna11 | guanine nucleotide binding protein, alpha 11
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton
18 No significant impact
2 Not tested
Gene metrics:15Significant phenotypes
9Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased hemoglobin content | 1 supporting dataset | Gna11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.26x10-21 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Gna11tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.34x10-10 | ||
| vertebral fusion | 1 supporting dataset | Gna11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.04x10-7 | ||
| increased circulating calcium level | 1 supporting dataset | Gna11tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.37x10-28 | ||
| decreased hematocrit | 1 supporting dataset | Gna11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.07x10-10 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Gna11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.24x10-8 | ||
| decreased circulating phosphate level | 1 supporting dataset | Gna11tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.08x10-5 | ||
| increased startle reflex | 3 supporting datasets | Gna11tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.6x10-5 | ||
| increased red blood cell distribution width | 1 supporting dataset | Gna11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.18x10-7 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Gna11tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.31x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Gna11 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gna11.
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| Gna11tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gna11tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |