Ghrh | growth hormone releasing hormone

GeneMGI:95709Synonyms: Ghrf

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased lean body mass	2 supporting datasets	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.48x10^-37
decreased heart weight	2 supporting datasets	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.05x10^-20
decreased grip strength	2 supporting datasets	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.97x10^-8
decreased fasting circulating glucose level	1 supporting dataset	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.1x10^-5
decreased body length	1 supporting dataset	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.42x10^-70
decreased bone mineral density	1 supporting dataset	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.48x10^-53
increased total body fat amount	2 supporting datasets	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.51x10^-41
decreased bone mineral content	2 supporting datasets	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.01x10^-41
impaired glucose tolerance	2 supporting datasets	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.32x10^-8
abnormal bone structure	1 supporting dataset	Ghrh^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.61x10^-41

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ghrh.

Associated images

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Histopathology

There is no histopathology data found for Ghrh.

IMPC related publications

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External links

No external links available for Ghrh.

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*Ghrh^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ghrh^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ghrh^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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