Gdf6 | growth differentiation factor 6
Physiological systems
24 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
13 No significant impact
Data collections
Gene metrics:13Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged thymus | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | homozygote | E18.5 | N/A * | ||
| abnormal digit morphology | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | 4.99x10-8 | ||
| abnormal brain morphology | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal optic disk morphology | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | 8.7x10-13 | ||
| abnormal retina morphology | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | 4.66x10-8 | ||
| abnormal spleen morphology | 2 supporting datasets | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| increased lung tissue damping | 1 supporting dataset | Gdf6em1(IMPC)Ccpcz | heterozygote | Early adult | 2.76x10-6 |
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Human diseases caused by Gdf6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gdf6.
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| Gdf6em1(IMPC)Ccpcz | Inter-exon deletion | | mouse |
| Gdf6tm181237(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Gdf6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Gdf6tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |