Gdf5 | growth differentiation factor 5
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton
13 No significant impact
6 Not tested
Data collections
Gene metrics:13Significant phenotypes
18Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased grip strength | 4 supporting datasets | Gdf5em1(IMPC)Bay | homozygote | Early adult | 1.83x10-38 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Gdf5em1(IMPC)H | homozygote | Early adult | 5.62x10-5 | ||
| abnormal hindlimb morphology | 2 supporting datasets | Gdf5em1(IMPC)H | homozygote | Early adult | 1.1x10-23 | ||
| abnormal bone structure | 1 supporting dataset | Gdf5em1(IMPC)Bay | homozygote | Early adult | 2.15x10-9 | ||
| abnormal bone structure | 1 supporting dataset | Gdf5em1(IMPC)H | homozygote | Early adult | 4.41x10-7 | ||
| abnormal digit morphology | 4 supporting datasets | Gdf5em1(IMPC)H | homozygote | Early adult | 1.1x10-23 | ||
| limb grasping | 1 supporting dataset | Gdf5em1(IMPC)H | homozygote | Early adult | 1.91x10-8 | ||
| abnormal autopod morphology | 4 supporting datasets | Gdf5em1(IMPC)H | homozygote | Early adult | 1.1x10-23 | ||
| decreased locomotor activity | 2 supporting datasets | Gdf5em1(IMPC)H | homozygote | Early adult | 1.52x10-5 | ||
| increased bone mineral density | 1 supporting dataset | Gdf5em1(IMPC)H | homozygote | Early adult | 5.11x10-5 |
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Human diseases caused by Gdf5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gdf5.
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