Gad2 | glutamic acid decarboxylase 2

GeneMGI:95634Synonyms: GAD(65), Gad-2, +2 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Behavior/neurological

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased thigmotaxis	2 supporting datasets	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.69x10^-6
decreased locomotor activity	2 supporting datasets	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.64x10^-8
decreased exploration in new environment	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.63x10^-7
increased circulating chloride level	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.83x10^-6
increased circulating sodium level	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.21x10^-6
increased fasting circulating glucose level	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.13x10^-6
impaired glucose tolerance	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.01x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.83x10^-7
increased vertical activity	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.64x10^-7
abnormal behavior	1 supporting dataset	Gad2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.68x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gad2.

Associated images

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Histopathology

There is no histopathology data found for Gad2.

IMPC related publications

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External links

No external links available for Gad2.

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*Gad2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Gad2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Gad2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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