Gabrg2 | gamma-aminobutyric acid type A receptor, subunit gamma 2
Physiological systems
22 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Endocrine/exocrine gland Integument Vision/eye Skeleton Mortality/aging Cardiovascular system
15 No significant impact
2 Not tested
Data collections
Gene metrics:10Significant phenotypes
7Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Gabrg2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | 1.69x10-5 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | 2.08x10-9 | ||
| decreased heart weight | 2 supporting datasets | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | 8.97x10-8 | ||
| enlarged testis | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal ovary morphology | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| decreased bone mineral content | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | 9.37x10-5 | ||
| abnormal testis morphology | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| decreased bone mineral density | 1 supporting dataset | Gabrg2em1(IMPC)Mbp | heterozygote | Early adult | 1.87x10-5 |
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Human diseases caused by Gabrg2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Gabrg2.
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| Gabrg2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Gabrg2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gabrg2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Gabrg2tm355(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Gabrg2tm355(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |