Gabra5 | gamma-aminobutyric acid type A receptor subunit alpha 5
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Cardiovascular system
15 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal thymus morphology | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| small spleen | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| small testis | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal testis morphology | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Gabra5em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Gabra5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gabra5.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Gabra5em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Gabra5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Gabra5tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |