Gabra2 | gamma-aminobutyric acid type A receptor subunit alpha 2
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:15Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Late adult | 2x10-5 | ||
| limb grasping | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Late adult | 1.5x10-6 | ||
| cornea opacity | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Early adult | 7.82x10-7 | ||
| decreased locomotor activity | 3 supporting datasets | Gabra2em1(IMPC)H | homozygote | Early adult | 9.6x10-9 | ||
| trunk curl | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Early adult | 8.43x10-6 | ||
| decreased heart rate | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Early adult | 2.97x10-5 | ||
| limb grasping | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Middle aged adult | 9.59x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Late adult | 1.02x10-6 | ||
| decreased exploration in new environment | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Late adult | 3.83x10-5 | ||
| increased lean body mass | 1 supporting dataset | Gabra2em1(IMPC)H | homozygote | Late adult | 5.03x10-7 |
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Human diseases caused by Gabra2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gabra2.
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| Gabra2em1(IMPC)H | Exon Deletion | | mouse |