Fgf3 | fibroblast growth factor 3
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Embryo Growth/size/body region Limbs/digits/tail Behavior/neurological Mortality/aging
15 No significant impact
3 Not tested
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues
| no spontaneous movement | 1 supporting dataset | Fgf3tm4b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Fgf3tm4b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Fgf3tm4b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Fgf3tm4b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Fgf3tm4b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| abnormal tail morphology | 2 supporting datasets | Fgf3tm4b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Fgf3tm4b(EUCOMM)Hmgu | heterozygote | E18.5 | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Fgf3tm4b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Fgf3tm4b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Fgf3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fgf3.
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| Fgf3tm4a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Fgf3tm4b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Fgf3tm4e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |