Ephx1 | epoxide hydrolase 1, microsomal
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological
16 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased startle reflex | 5 supporting datasets | Ephx1Ephx1 | homozygote | Early adult | 6.2x10-12 | ||
| increased mean corpuscular volume | 1 supporting dataset | Ephx1Ephx1 | homozygote | Early adult | 5.24x10-5 | ||
| increased IgA level | 1 supporting dataset | Ephx1Ephx1 | homozygote | Early adult | 1.04x10-5 | ||
| increased circulating potassium level | 1 supporting dataset | Ephx1Ephx1 | homozygote | Early adult | 6.77x10-5 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Ephx1Ephx1 | homozygote | Early adult | 7.23x10-6 | ||
| thrombocytopenia | 1 supporting dataset | Ephx1Ephx1 | homozygote | Early adult | 6.36x10-9 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Ephx1Ephx1 | homozygote | Early adult | 6.65x10-6 |
| | | | | | | | | | |
Human diseases caused by Ephx1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ephx1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ephx1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Ephx1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ephx1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Ephx1tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ephx1tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |