Ect2 | ect2 oncogene

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Hearing/vestibular/ear Behavior/neurological Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetEct2tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal auditory brainstem response1 supporting datasetEct2tm1b(EUCOMM)WtsiheterozygoteEarly adult5.11x10-5 
decreased grip strength1 supporting datasetEct2tm1b(EUCOMM)WtsiheterozygoteEarly adult8.63x10-6 
tremors1 supporting datasetEct2tm1b(EUCOMM)WtsiheterozygoteEarly adult9.47x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ect2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Ect2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ect2tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Ect2tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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