Bach2 | BTB and CNC homology, basic leucine zipper transcription factor 2
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Limbs/digits/tail Nervous system Vision/eye Respiratory system Hematopoietic system Behavior/neurological Skeleton
12 No significant impact
3 Not tested
Data collections
Gene metrics:65Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased monocyte cell number | 3 supporting datasets | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased Ly6C high monocyte number | 1 supporting dataset | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased prepulse inhibition | 5 supporting datasets | Bach2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.04x10-8 | ||
| increased Ly6C low monocyte number | 1 supporting dataset | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased B cell number | 1 supporting dataset | Bach2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.53x10-11 | ||
| increased memory-marker NK cell number | 4 supporting datasets | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | 4 supporting datasets | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased KLRG1+ CD8 alpha-beta T cell number | 6 supporting datasets | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased KLRG1+ CD4 alpha-beta T cell number | 4 supporting datasets | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | 8 supporting datasets | Bach2tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Bach2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Bach2.
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| Bach2tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Bach2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Bach2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Bach2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Bach2tm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |