Scarb1 | scavenger receptor class B, member 1

GeneMGI:893578Synonyms: Cla-1, Chohd1, +7 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

1Associated diseases

Expression examined in:49Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



cardiovascular system phenotype	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.85x10^-5
increased circulating cholesterol level	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.44x10^-17
abnormal sinus arrhythmia	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.76x10^-9
prolonged RR interval	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.46x10^-7
decreased heart rate	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.76x10^-6
prolonged ST segment	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.72x10^-5
increased heart weight	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.5x10^-5
enlarged heart	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.19x10^-7
decreased vertical activity	1 supporting dataset	Scarb1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.11x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Scarb1.

Associated images

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Histopathology

There is no histopathology data found for Scarb1.

IMPC related publications

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External links

No external links available for Scarb1.

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*Scarb1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Scarb1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Scarb1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Scarb1^{tm358832(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Scarb1^{tm41571(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Scarb1^{tm41571(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Scarb1^{tm41571(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Scarb1^{tm41571(L1L2_st2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes