Scarb1 | scavenger receptor class B, member 1
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system
12 No significant impact
6 Not tested
Data collections
Gene metrics:12Significant phenotypes
1Associated diseases
Expression examined in:49Adult tissues
0Embryo tissues
| cardiovascular system phenotype | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.85x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.44x10-17 | ||
| abnormal sinus arrhythmia | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.76x10-9 | ||
| prolonged RR interval | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.46x10-7 | ||
| decreased heart rate | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.76x10-6 | ||
| prolonged ST segment | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.72x10-5 | ||
| increased heart weight | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.5x10-5 | ||
| enlarged heart | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased spleen weight | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.19x10-7 | ||
| decreased vertical activity | 1 supporting dataset | Scarb1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.11x10-5 |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Scarb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Scarb1.
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| Scarb1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Scarb1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Scarb1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Scarb1tm358832(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Scarb1tm41571(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Scarb1tm41571(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Scarb1tm41571(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Scarb1tm41571(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |